Cushing's syndrome as a paraneoplastic feature of renal cell carcinoma: A case report

Asaad Moradi; Nasrollah Abian; Behnam Shakiba; Kiarash Moradi; Leyla Arefian

doi:10.1016/j.eucr.2023.102504

Cushing's syndrome as a paraneoplastic feature of renal cell carcinoma: A case report

Urol Case Rep. 2023 Jul 13:50:102504. doi: 10.1016/j.eucr.2023.102504. eCollection 2023 Sep.

Authors

Asaad Moradi¹, Nasrollah Abian², Behnam Shakiba¹, Kiarash Moradi¹, Leyla Arefian³

Affiliations

¹ Department of Urology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
² Department of Urology, 5 Azar Hospital, School of Medicine, Golestan University of Medical Sciences and Health Services, Gorgan, Iran.
³ Department of Pathology, Aban General Hospital, Tehran, Iran.

Abstract

Cushing's syndrome has been believed to be a paraneoplastic syndrome of renal cell carcinomas. However, there appears to be a dearth of compelling evidence to substantiate this notion. The only eligible documentation of Cushing's syndrome due to ectopic adrenocorticotropic hormone secretion by renal cancer in English literature dates back to 1988, and it pertains to a deceased patient discovered during an autopsy. Here, we present the first case of Cushing's syndrome as a paraneoplastic feature of renal cancer which showed complete resolution following surgical removal of the tumor. Additionally, we conduct review of the literature on this particular subject.

Keywords: ACTH; Cushing's syndrome; Paraneoplastic syndrome; RCC.

Publication types

Case Reports